Can you open the same file in other programs? Just wondering if its an Gimp APNG plug-in issue or your system has an issue opening PNG file types. Possibly Gimp doesn't know the file type even though it has an PNG extension.

I just opened a png image in paint.net and it opened up with no problems.

How do I solve the desktop.ini file issue showing up in gimp when I try to open an image?

Then my guess is that if you could open PNG files in Gimp before this then its not a PNG file you are trying to open (but paint.net) understands the extension. Have you tried to open PNG files IN GIMP that this program has created before? If not try renaming the file to another extension such as JPG or GIF (Create a duplicate first). If they will then open in GIMP they probably are not PNG files that GIMP understands as a PNG or an Animated APNG file.

If you still have problems upload one here and i will see if i can open it in Gimp.

I have opened PNG files in GIMP before. Many many times, in fact and they have worked. It happens to all of the images I open in gimp. It happened earlier today, after I tried for the 10th time to try to install the Ulead effects properly. I have given up on those. Maybe that's what has caused the problem.

Check if your Gimp installation still has the "file-*" plugins in the plugins directory (see "Edit > Preferences > Folders > Plugins" for the location of the folders that Gimp scans for plugins (normally "C:/Program files/GIMP/lib/gimp/2.0/plug-ins/file-png.exe")

Try this,
Right click the file and select open with and select Gimp as the program. Close Gimp first.
That should associate PNG files with Gimp again.

Does it happen in Gimp every time you open any image extension?

try this... make a quick doodle in gimp and export as a ping. close the image and try to reopen it.
If it opens then the previous images you have tried to open have an issue. If it doesnt then the issue is with gimp.

A Desktop.ini file is a hidden Windows operating system configuration settings file located in every folder, that determines how the folder is displayed along with its other Properties – like the icon used for that folder, its localized name, sharing properties, etc.
Do not delete it, you need to hide it.
1. Open Windows Explorer or press Windows Key + E.
2. Click View > Options.
3. Click the View tab.
4. Click on the Hide protected operating system files checkbox.
5. Click OK.
[ Image ]


Now, for the png that won't open. Did you deleted anything from you Main GIMP 2 program C:\Program Files\GIMP 2\lib\gimp\2.0\plug-ins?

I had an identical case once - caused by one dll file in the wrong place. Did you clean up ...\lib\gimp\2.0\plug-ins\... ?