There are ways using stock Gimp tools, for example it is possible to place guides at the end of the measure tool. Might be awkward with a Mac / trackpad.
However there are a couple of utilities to place guides using other than pixels. This one was proposed by one of the Gimp team but never implemented. A script guide-new-unit.scm Put that in your user scripts folder, wherever that is in a Mac.
Attachment:
01-newguide.jpg [ 52.91 KiB | Viewed 1951 times ]
or
One of arakne's python plugins arakne-guide-lab Two files and a folder, go in the user plugins folder arakne-guide-lab.py , drawUI.py, locales. Might work in a Mac. Make sure the .py files are marked as executable.
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02-newguide.jpg [ 81.47 KiB | Viewed 1951 times ]
Of course, Gimp still works in pixels, so there is always some rounding off. Use a large canvas to give more chance of hitting the best pixel
All zipped and attached.