Closeups everywhere!

Nice to see a close character study from you merrak, you have done several semi-close faces before, don't remember seeing anything as close-portrait as this before though.
She certainly looks special and kinda spooky! I think the issue with her eye has to do with the perspective plane of the face being off. Her left eye (our right) is too close to us and the plane of her eyes are shifted towards us much more than the plane of her nose and mouth.
You picked a very tricky angle here, depicting the underside of the chin from a lower angle is very difficult since we are not used to see other people from this angle (well, unless you are very short I guess). She has a pretty large chin, but that is by all means not impossible to have! I think the shading of the chin is conusing the eye though - the "bump" in her chin is extending too far to our left, making it look like her entire lower face is skewed to that side rather than just facing forward.
The hair works fine, it's quite thin but since she's a ghost that is probably as intended. Overall she looks quite sickly, again this fits well with the ghost theme.
I suggest mirroring this image both vertically and horizontally, the perspective issues should come across more clearly then. Maybe use something like
this pose from posemaniacs as a reference to get a handle on the facial planes from this angle?
Just some suggestion of course. Cool study, very useful to go, as you say, "out of your comfort zone", those are the images one usually learn the most from.

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Griatch