there is a interesting variant of Wine QT4wine
http://sourceforge.net/projects/q4wine/ the main difference are
1) it has a GUI
2) It allows to have more then 1 windows directory ( so you may as example use software that would be incompatible, i.e different version of same programs ,without conflict )
It is more simple to use but the set up was less automatic( no too complex; you just must confirm or correct the paths for your wine install,i.e the path for the wine executive, that for its libraries , where you want a virtual C drive(s)..)
It should be in the Fedora repository (even if i doubt they could have already the last version because was released few days ago,) so you don't need to compile, installation is automatic ...except that at a certain point you will have to confirm that few paths
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